OpenMRS is an open-source medical record system used in developing countries. The University of Toronto and affiliated Canadian researchers are among the primary contributors to its core platform and modules, helping deliver healthcare technology globally.

Freenet is a peer-to-peer platform for censorship-resistant communication and publishing. Ian Clarke, whose work has strong Canadian roots, created the project. Canadian privacy advocates and technical contributors have been essential to the project's ongoing development and adoption.

SageMath is a free open-source mathematics software system. The Pacific Institute for the Mathematical Sciences (PIMS), a consortium of Canadian universities, provides infrastructure and hosting for SageMath and has been a key institutional backer of open mathematical software in Canada.

OSCAR EMR (Open Source Clinical Application Resource) is a Canadian-developed open-source electronic medical records system used by thousands of primary care physicians across Canada. Developed at McMaster University, it supports bilingual interfaces and Canadian-specific clinical workflows including OHIP billing.