The Digital Research Alliance of Canada (formerly Compute Canada) manages national HPC clusters running customized Slurm workload manager configurations and contributes open-source tooling for scientific computing. Their open-source stack powers university research across the country.

OpenHMD is a free and open-source API and drivers for immersive technology such as head-mounted displays (VR/AR). Canadian developers have been central contributors, and the project supports a wide range of VR headsets on Linux.

Canadian research networks including CANARIE and provincial NREN members such as ORION and BCNET are major contributors to open-source network authentication and AAI infrastructure. Their contributions to FreeRADIUS and eduroam infrastructure enable secure network access for millions of students and researchers.

CANARIE manages the Canadian Access Federation (CAF), which provides open-source Shibboleth identity federation infrastructure enabling single sign-on for over 300 Canadian universities, colleges, and research institutions. Their open tools and configuration guides are publicly available.

OpenMRS is an open-source medical record system used in developing countries. The University of Toronto and affiliated Canadian researchers are among the primary contributors to its core platform and modules, helping deliver healthcare technology globally.

The National Research Council of Canada (NRC) publishes numerous open-source tools and datasets for materials science, climate modelling, construction standards, and aerospace research. Their open-data and open-software initiatives are publicly available via the Government of Canada's open resource portal.

Statistics Canada releases open-source tools and R/Python packages for statistical analysis and data dissemination. Their tools include the Canadian Statistical Dissemination Architecture (CSDA), open microdata tools, and visualization packages used by researchers across Canada.

Freenet is a peer-to-peer platform for censorship-resistant communication and publishing. Ian Clarke, whose work has strong Canadian roots, created the project. Canadian privacy advocates and technical contributors have been essential to the project's ongoing development and adoption.

Axiom is a free, open-source computer algebra system with a long history. Canadian mathematicians supported through NSERC (Natural Sciences and Engineering Research Council) have contributed significantly to its formal mathematics libraries and documentation.

OpenStax provides free, peer-reviewed open-source textbooks. Toronto Metropolitan University (TMU) and several other Canadian institutions are active contributors to the platform's open educational resources and have helped adapt content for Canadian curricula.

Developed by the National Research Council of Canada, the NRC Word-Emotion Association Lexicon (EmoLex) is a widely-cited open linguistic resource mapping words to emotions and sentiments. It is freely available for research and has been used in thousands of NLP studies worldwide.

OSCAR EMR (Open Source Clinical Application Resource) is a Canadian-developed open-source electronic medical records system used by thousands of primary care physicians across Canada. Developed at McMaster University, it supports bilingual interfaces and Canadian-specific clinical workflows including OHIP billing.