The Digital Research Alliance of Canada (formerly Compute Canada) manages national HPC clusters running customized Slurm workload manager configurations and contributes open-source tooling for scientific computing. Their open-source stack powers university research across the country.

CANARIE manages the Canadian Access Federation (CAF), which provides open-source Shibboleth identity federation infrastructure enabling single sign-on for over 300 Canadian universities, colleges, and research institutions. Their open tools and configuration guides are publicly available.

OpenMRS is an open-source medical record system used in developing countries. The University of Toronto and affiliated Canadian researchers are among the primary contributors to its core platform and modules, helping deliver healthcare technology globally.

OpenStax provides free, peer-reviewed open-source textbooks. Toronto Metropolitan University (TMU) and several other Canadian institutions are active contributors to the platform's open educational resources and have helped adapt content for Canadian curricula.

OSCAR EMR (Open Source Clinical Application Resource) is a Canadian-developed open-source electronic medical records system used by thousands of primary care physicians across Canada. Developed at McMaster University, it supports bilingual interfaces and Canadian-specific clinical workflows including OHIP billing.